Quantification of cardiac fiber orientation using optical coherence tomography.

نویسندگان

  • Christine P Fleming
  • Crystal M Ripplinger
  • Bryan Webb
  • Igor R Efimov
  • Andrew M Rollins
چکیده

Heterogeneity in cardiac tissue microstructure is a potential mechanism for the generation and maintenance of arrhythmias. Abnormal changes in fiber orientation increase the likelihood of arrhythmia. We present optical coherence tomography (OCT) as a method to image myofibers in excised intact heart preparations. Three-dimensional (3-D) image sets were gathered from the rabbit right ventricular free wall (RVFW) using a microscope-integrated OCT system. An automated algorithm for fiber orientation quantification in the plane parallel to the wall surface was developed. The algorithm was validated by comparison with manual measurements. Quantifying fiber orientation in the plane parallel to the wall surface from OCT images can be used to help understand the conduction system of the specific sample being imaged.

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عنوان ژورنال:
  • Journal of biomedical optics

دوره 13 3  شماره 

صفحات  -

تاریخ انتشار 2008